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1048: 26 Residue Peptide Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 05, 2015
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 9,653
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 84 pts. 9,614
  3. Avatar for L'Alliance Francophone 3. L'Alliance Francophone 70 pts. 9,603
  4. Avatar for Go Science 4. Go Science 58 pts. 9,599
  5. Avatar for Gargleblasters 5. Gargleblasters 48 pts. 9,579
  6. Avatar for Deleted group 6. Deleted group pts. 9,560
  7. Avatar for Contenders 7. Contenders 32 pts. 9,555
  8. Avatar for Void Crushers 8. Void Crushers 26 pts. 9,537
  9. Avatar for SETI.Germany 9. SETI.Germany 20 pts. 9,507
  10. Avatar for Herobrine's Army 10. Herobrine's Army 16 pts. 9,489
  1. Avatar for greepski 31. greepski Lv 1 1 pt. 9,525
  2. Avatar for spvincent 32. spvincent Lv 1 1 pt. 9,498
  3. Avatar for Blipperman 33. Blipperman Lv 1 1 pt. 9,479
  4. Avatar for O Seki To 34. O Seki To Lv 1 1 pt. 8,927
  5. Avatar for test_account1 35. test_account1 Lv 1 1 pt. 6,289
  6. Avatar for jflat06 36. jflat06 Lv 1 1 pt. 6,228
  7. Avatar for test_account2 37. test_account2 Lv 1 1 pt. 6,228

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.