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1048: 26 Residue Peptide Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 05, 2015
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 9,653
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 84 pts. 9,614
  3. Avatar for L'Alliance Francophone 3. L'Alliance Francophone 70 pts. 9,603
  4. Avatar for Go Science 4. Go Science 58 pts. 9,599
  5. Avatar for Gargleblasters 5. Gargleblasters 48 pts. 9,579
  6. Avatar for Deleted group 6. Deleted group pts. 9,560
  7. Avatar for Contenders 7. Contenders 32 pts. 9,555
  8. Avatar for Void Crushers 8. Void Crushers 26 pts. 9,537
  9. Avatar for SETI.Germany 9. SETI.Germany 20 pts. 9,507
  10. Avatar for Herobrine's Army 10. Herobrine's Army 16 pts. 9,489
  1. Avatar for krogmonster 121. krogmonster Lv 1 6 pts. 8,433
  2. Avatar for Altercomp 122. Altercomp Lv 1 6 pts. 8,422
  3. Avatar for rinze 123. rinze Lv 1 6 pts. 8,422
  4. Avatar for tzabaoth 124. tzabaoth Lv 1 6 pts. 8,418
  5. Avatar for Lindata 125. Lindata Lv 1 6 pts. 8,406
  6. Avatar for wudoo 126. wudoo Lv 1 6 pts. 8,406
  7. Avatar for Jim Fraser 127. Jim Fraser Lv 1 5 pts. 8,405
  8. Avatar for Iron pet 128. Iron pet Lv 1 5 pts. 8,401
  9. Avatar for mirjamvandelft 129. mirjamvandelft Lv 1 5 pts. 8,400
  10. Avatar for Ernst Zundel 130. Ernst Zundel Lv 1 5 pts. 8,397

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.