Placeholder image of a protein
Icon representing a puzzle

1052: 80 Residue Symmetric Trimer Design

Closed since about 11 years ago

Intermediate Overall Design Symmetry

Summary

Created
February 13, 2015
Expires
Max points
100
Description

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 11. Russian team 9 pts. 14,621
  2. Avatar for Deleted group 12. Deleted group pts. 14,334
  3. Avatar for Herobrine's Army 13. Herobrine's Army 5 pts. 13,903
  4. Avatar for Natural Abilities 14. Natural Abilities 4 pts. 12,781
  5. Avatar for It's over 9000! 15. It's over 9000! 3 pts. 12,283
  6. Avatar for freefolder 16. freefolder 2 pts. 12,104
  7. Avatar for xkcd 17. xkcd 1 pt. 10,783
  8. Avatar for Italiani Al Lavoro 18. Italiani Al Lavoro 1 pt. 9,209
  9. Avatar for FoldIt@Netherlands 19. FoldIt@Netherlands 1 pt. 8,961
  10. Avatar for Eὕρηκα! Heureka! 20. Eὕρηκα! Heureka! 1 pt. 8,882
  1. Avatar for jermainiac 211. jermainiac Lv 1 1 pt. 0
  2. Avatar for Carlos7992 212. Carlos7992 Lv 1 1 pt. 0
  3. Avatar for Imeturoran 213. Imeturoran Lv 1 1 pt. 0
  4. Avatar for larry25427 214. larry25427 Lv 1 1 pt. 0
  5. Avatar for IHGreenman 215. IHGreenman Lv 1 1 pt. 0
  6. Avatar for nmos1056 216. nmos1056 Lv 1 1 pt. 0
  7. Avatar for aspadistra 217. aspadistra Lv 1 1 pt. 0
  8. Avatar for Deleted player 218. Deleted player pts. 0
  9. Avatar for MadTrumpeter 219. MadTrumpeter Lv 1 1 pt. 0
  10. Avatar for Johnrqrqrq 220. Johnrqrqrq Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 27% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 32% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.