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1052: 80 Residue Symmetric Trimer Design

Closed since about 11 years ago

Intermediate Overall Design Symmetry

Summary

Created
February 13, 2015
Expires
Max points
100
Description

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 0
  5. Avatar for Team Schleswig-Holstein 25. Team Schleswig-Holstein 1 pt. 0
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  4. Avatar for BCAA 74. BCAA Lv 1 14 pts. 12,283
  5. Avatar for steveB 75. steveB Lv 1 14 pts. 12,151
  6. Avatar for Altercomp 76. Altercomp Lv 1 13 pts. 12,104
  7. Avatar for Petrifolder 77. Petrifolder Lv 1 13 pts. 11,965
  8. Avatar for tzabaoth 78. tzabaoth Lv 1 12 pts. 11,942
  9. Avatar for mottiger 79. mottiger Lv 1 12 pts. 11,888
  10. Avatar for ponderosa 80. ponderosa Lv 1 11 pts. 11,642

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 27% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 32% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.