Placeholder image of a protein
Icon representing a puzzle

1052: 80 Residue Symmetric Trimer Design

Closed since about 11 years ago

Intermediate Overall Design Symmetry

Summary

Created
February 13, 2015
Expires
Max points
100
Description

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 16,279
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 83 pts. 16,136
  3. Avatar for L'Alliance Francophone 3. L'Alliance Francophone 68 pts. 16,078
  4. Avatar for Go Science 4. Go Science 55 pts. 15,925
  5. Avatar for Void Crushers 5. Void Crushers 44 pts. 15,851
  6. Avatar for HMT heritage 6. HMT heritage 35 pts. 15,515
  7. Avatar for Deleted group 7. Deleted group pts. 15,237
  8. Avatar for Gargleblasters 8. Gargleblasters 21 pts. 14,968
  9. Avatar for Contenders 9. Contenders 16 pts. 14,915
  10. Avatar for SETI.Germany 10. SETI.Germany 12 pts. 14,750
  1. Avatar for Sissue 31. Sissue Lv 1 49 pts. 14,757
  2. Avatar for Bautho 32. Bautho Lv 1 47 pts. 14,750
  3. Avatar for g_b 33. g_b Lv 1 46 pts. 14,745
  4. Avatar for dcrwheeler 34. dcrwheeler Lv 1 45 pts. 14,744
  5. Avatar for cbwest 35. cbwest Lv 1 44 pts. 14,698
  6. Avatar for spvincent 36. spvincent Lv 1 43 pts. 14,690
  7. Avatar for Grom 37. Grom Lv 1 42 pts. 14,621
  8. Avatar for bcd 38. bcd Lv 1 41 pts. 14,564
  9. Avatar for gloverd 39. gloverd Lv 1 39 pts. 14,548
  10. Avatar for drumpeter18yrs9yrs 40. drumpeter18yrs9yrs Lv 1 38 pts. 14,334

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 27% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 32% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.