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1057: 26 Residue Peptide Design: More Sheets!

Closed since about 11 years ago

Intermediate Overall Design

Summary


Created
February 26, 2015
Expires
Max points
100
Description

Like Puzzle 1048, this puzzle is aimed at designing short peptides that fold into stable structures, now with an emphasis on designed sheets! See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for SETIKAH@KOREA 21. SETIKAH@KOREA 1 pt. 7,427
  2. Avatar for Deleted group 22. Deleted group pts. 7,384
  3. Avatar for BOINC@Poland 23. BOINC@Poland 1 pt. 7,306
  4. Avatar for Chem233W15 24. Chem233W15 1 pt. 7,212
  5. Avatar for Crunching Family 25. Crunching Family 1 pt. 7,197
  6. Avatar for Deleted group 26. Deleted group pts. 7,149
  7. Avatar for DSN @ Home 27. DSN @ Home 1 pt. 6,304

  1. Avatar for mitarcher 131. mitarcher Lv 1 4 pts. 8,529
  2. Avatar for Dantoto 132. Dantoto Lv 1 3 pts. 8,525
  3. Avatar for Continental_Drift 133. Continental_Drift Lv 1 3 pts. 8,515
  4. Avatar for tornado163 134. tornado163 Lv 1 3 pts. 8,509
  5. Avatar for matosfran 135. matosfran Lv 1 3 pts. 8,509
  6. Avatar for Arne Heessels 136. Arne Heessels Lv 1 3 pts. 8,497
  7. Avatar for pandabearsecond 137. pandabearsecond Lv 1 3 pts. 8,478
  8. Avatar for oldgum 138. oldgum Lv 1 3 pts. 8,442
  9. Avatar for brgreening 139. brgreening Lv 1 3 pts. 8,389
  10. Avatar for jcs_stroke 140. jcs_stroke Lv 1 3 pts. 8,362

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.

Secondary Structure: Checks that at least 6 residues form sheets; penalties are incurred if fewer than 6 residues form sheets.