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1057: 26 Residue Peptide Design: More Sheets!

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 26, 2015
Expires
Max points
100
Description

Like Puzzle 1048, this puzzle is aimed at designing short peptides that fold into stable structures, now with an emphasis on designed sheets! See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for SETIKAH@KOREA 21. SETIKAH@KOREA 1 pt. 7,427
  2. Avatar for Deleted group 22. Deleted group pts. 7,384
  3. Avatar for BOINC@Poland 23. BOINC@Poland 1 pt. 7,306
  4. Avatar for Chem233W15 24. Chem233W15 1 pt. 7,212
  5. Avatar for Crunching Family 25. Crunching Family 1 pt. 7,197
  6. Avatar for Deleted group 26. Deleted group pts. 7,149
  7. Avatar for DSN @ Home 27. DSN @ Home 1 pt. 6,304
  1. Avatar for Dagal 191. Dagal Lv 1 1 pt. 7,526
  2. Avatar for Featherstonehaugh 192. Featherstonehaugh Lv 1 1 pt. 7,467
  3. Avatar for Sydefecks 193. Sydefecks Lv 1 1 pt. 7,462
  4. Avatar for Johnrqrqrq 194. Johnrqrqrq Lv 1 1 pt. 7,458
  5. Avatar for gardenpea 195. gardenpea Lv 1 1 pt. 7,427
  6. Avatar for lighttp 196. lighttp Lv 1 1 pt. 7,384
  7. Avatar for blacknemesis 197. blacknemesis Lv 1 1 pt. 7,380
  8. Avatar for bamh 198. bamh Lv 1 1 pt. 7,364
  9. Avatar for Person Personsonn 199. Person Personsonn Lv 1 1 pt. 7,331
  10. Avatar for kitek314_pl 200. kitek314_pl Lv 1 1 pt. 7,306

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.

Secondary Structure: Checks that at least 6 residues form sheets; penalties are incurred if fewer than 6 residues form sheets.