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1057: 26 Residue Peptide Design: More Sheets!

Closed since about 11 years ago

Intermediate Overall Design

Summary


Created
February 26, 2015
Expires
Max points
100
Description

Like Puzzle 1048, this puzzle is aimed at designing short peptides that fold into stable structures, now with an emphasis on designed sheets! See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for SETIKAH@KOREA 21. SETIKAH@KOREA 1 pt. 7,427
  2. Avatar for Deleted group 22. Deleted group pts. 7,384
  3. Avatar for BOINC@Poland 23. BOINC@Poland 1 pt. 7,306
  4. Avatar for Chem233W15 24. Chem233W15 1 pt. 7,212
  5. Avatar for Crunching Family 25. Crunching Family 1 pt. 7,197
  6. Avatar for Deleted group 26. Deleted group pts. 7,149
  7. Avatar for DSN @ Home 27. DSN @ Home 1 pt. 6,304

  1. Avatar for benbennett 211. benbennett Lv 1 1 pt. 7,084
  2. Avatar for erzer54899 212. erzer54899 Lv 1 1 pt. 7,000
  3. Avatar for Durelone 213. Durelone Lv 1 1 pt. 6,772
  4. Avatar for Close At Hand 214. Close At Hand Lv 1 1 pt. 6,709
  5. Avatar for plucheke 215. plucheke Lv 1 1 pt. 6,506
  6. Avatar for aspadistra 216. aspadistra Lv 1 1 pt. 6,304
  7. Avatar for rdungan 217. rdungan Lv 1 1 pt. 6,000
  8. Avatar for Daniel08ger 218. Daniel08ger Lv 1 1 pt. 5,979
  9. Avatar for hias90 219. hias90 Lv 1 1 pt. 5,947
  10. Avatar for biochem15 220. biochem15 Lv 1 1 pt. 5,855

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.

Secondary Structure: Checks that at least 6 residues form sheets; penalties are incurred if fewer than 6 residues form sheets.