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1057: 26 Residue Peptide Design: More Sheets!

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 26, 2015
Expires
Max points
100
Description

Like Puzzle 1048, this puzzle is aimed at designing short peptides that fold into stable structures, now with an emphasis on designed sheets! See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for SETIKAH@KOREA 21. SETIKAH@KOREA 1 pt. 7,427
  2. Avatar for Deleted group 22. Deleted group pts. 7,384
  3. Avatar for BOINC@Poland 23. BOINC@Poland 1 pt. 7,306
  4. Avatar for Chem233W15 24. Chem233W15 1 pt. 7,212
  5. Avatar for Crunching Family 25. Crunching Family 1 pt. 7,197
  6. Avatar for Deleted group 26. Deleted group pts. 7,149
  7. Avatar for DSN @ Home 27. DSN @ Home 1 pt. 6,304
  1. Avatar for orrinclerk 221. orrinclerk Lv 1 1 pt. 5,844
  2. Avatar for leehaggis 222. leehaggis Lv 1 1 pt. 5,819
  3. Avatar for MadTrumpeter 223. MadTrumpeter Lv 1 1 pt. 5,766
  4. Avatar for xingxing chen 224. xingxing chen Lv 1 1 pt. 5,738
  5. Avatar for Dhalion 225. Dhalion Lv 1 1 pt. 5,697
  6. Avatar for proteinbuilder123 226. proteinbuilder123 Lv 1 1 pt. 5,647
  7. Avatar for jaelyn.belt 227. jaelyn.belt Lv 1 1 pt. 5,630
  8. Avatar for Neuraminidase N9 228. Neuraminidase N9 Lv 1 1 pt. 5,629
  9. Avatar for Rick Topinka 229. Rick Topinka Lv 1 1 pt. 5,629
  10. Avatar for csa2125 230. csa2125 Lv 1 1 pt. 5,628

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.

Secondary Structure: Checks that at least 6 residues form sheets; penalties are incurred if fewer than 6 residues form sheets.