Placeholder image of a protein
Icon representing a puzzle

1057: 26 Residue Peptide Design: More Sheets!

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 26, 2015
Expires
Max points
100
Description

Like Puzzle 1048, this puzzle is aimed at designing short peptides that fold into stable structures, now with an emphasis on designed sheets! See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 10,124
  2. Avatar for Beta Folders 2. Beta Folders 83 pts. 10,095
  3. Avatar for Gargleblasters 3. Gargleblasters 68 pts. 10,078
  4. Avatar for Go Science 4. Go Science 55 pts. 10,071
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 44 pts. 10,050
  6. Avatar for Void Crushers 6. Void Crushers 35 pts. 10,048
  7. Avatar for Contenders 7. Contenders 27 pts. 10,044
  8. Avatar for Deleted group 8. Deleted group pts. 10,014
  9. Avatar for SETI.Germany 9. SETI.Germany 16 pts. 9,975
  10. Avatar for Deleted group 10. Deleted group pts. 9,892
  1. Avatar for dldahlen 171. dldahlen Lv 1 1 pt. 7,737
  2. Avatar for nlvsap94 172. nlvsap94 Lv 1 1 pt. 7,730
  3. Avatar for Andi1960 173. Andi1960 Lv 1 1 pt. 7,724
  4. Avatar for MadCat08 174. MadCat08 Lv 1 1 pt. 7,719
  5. Avatar for hqztrue 175. hqztrue Lv 1 1 pt. 7,707
  6. Avatar for rinze 176. rinze Lv 1 1 pt. 7,695
  7. Avatar for mimo31 177. mimo31 Lv 1 1 pt. 7,689
  8. Avatar for Philippe_C 178. Philippe_C Lv 1 1 pt. 7,686
  9. Avatar for Tac1 179. Tac1 Lv 1 1 pt. 7,682
  10. Avatar for krogmonster 180. krogmonster Lv 1 1 pt. 7,664

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.

Secondary Structure: Checks that at least 6 residues form sheets; penalties are incurred if fewer than 6 residues form sheets.