Placeholder image of a protein
Icon representing a puzzle

1062: 85 Residue Monomer Design: Zero Cysteines

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
March 10, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Deleted group 11. Deleted group pts. 9,847
  2. Avatar for HMT heritage 12. HMT heritage 7 pts. 9,682
  3. Avatar for Russian team 13. Russian team 5 pts. 9,450
  4. Avatar for SETI.Germany 14. SETI.Germany 4 pts. 9,038
  5. Avatar for FoldIt@Netherlands 15. FoldIt@Netherlands 3 pts. 8,667
  6. Avatar for freefolder 16. freefolder 2 pts. 8,395
  7. Avatar for xkcd 17. xkcd 1 pt. 8,049
  8. Avatar for Deleted group 19. Deleted group pts. 7,617
  9. Avatar for Natural Abilities 20. Natural Abilities 1 pt. 7,351

  1. Avatar for MurloW
    1. MurloW Lv 1
    100 pts. 10,591
  2. Avatar for BitSpawn 2. BitSpawn Lv 1 98 pts. 10,558
  3. Avatar for johnmitch 3. johnmitch Lv 1 96 pts. 10,526
  4. Avatar for eusair 4. eusair Lv 1 94 pts. 10,516
  5. Avatar for spvincent 5. spvincent Lv 1 93 pts. 10,494
  6. Avatar for Museka 6. Museka Lv 1 91 pts. 10,474
  7. Avatar for retiredmichael 7. retiredmichael Lv 1 89 pts. 10,450
  8. Avatar for spmm 8. spmm Lv 1 87 pts. 10,418
  9. Avatar for Galaxie 9. Galaxie Lv 1 85 pts. 10,391
  10. Avatar for zeroblue 10. zeroblue Lv 1 83 pts. 10,388

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.