1065: 90 Residue Monomer Design: Zero Cysteines

Closed since almost 11 years ago

Summary

• Created: March 18, 2015
• Expires: March 26, 2015 at 07:00 UTC
• Max points: 100

Description

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Anthropic Dreams 100 pts. 10,803
• 2. Beta Folders 84 pts. 10,750
• 3. Contenders 70 pts. 10,685
• 4. L'Alliance Francophone 57 pts. 10,648
• 5. Go Science 47 pts. 10,645
• 6. Void Crushers 38 pts. 10,597
• 7. Gargleblasters 30 pts. 10,280
• 8. Deleted group pts. 10,142
• 9. Deleted group pts. 9,991
• 10. HMT heritage 15 pts. 9,533

Top evolvers

• 11. smilingone 20 pts. 10,743
• 12. Deleted player pts. 10,742
• 13. brgreening 14 pts. 10,739
• 14. lamoille 11 pts. 10,722
• 15. alwen 9 pts. 10,722
• 16. Bletchley Park 7 pts. 10,685
• 17. gloverd 6 pts. 10,645
• 18. Bruno Kestemont 5 pts. 10,644
• 19. mirp 4 pts. 10,615
• 20. mimi 3 pts. 10,611

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.