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1065: 90 Residue Monomer Design: Zero Cysteines

Closed since about 11 years ago

Intermediate Overall Design

Summary


Created
March 18, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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  1. Avatar for multaq 211. multaq Lv 1 1 pt. 0
  2. Avatar for Deleted player 212. Deleted player pts. 0
  3. Avatar for Susume 213. Susume Lv 1 1 pt. 0
  4. Avatar for macpuddock 214. macpuddock Lv 1 1 pt. 0
  5. Avatar for jflat06 215. jflat06 Lv 1 1 pt. 0
  6. Avatar for jasonyangmx 216. jasonyangmx Lv 1 1 pt. 0
  7. Avatar for reubenj 217. reubenj Lv 1 1 pt. 0
  8. Avatar for puxatudo 218. puxatudo Lv 1 1 pt. 0
  9. Avatar for phi16 219. phi16 Lv 1 1 pt. 0
  10. Avatar for xtek23x 220. xtek23x Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.