Placeholder image of a protein
Icon representing a puzzle

1070: 75 Residue Symmetric Dimer Design

Closed since almost 11 years ago

Intermediate Overall Design Symmetry

Summary

Created
April 02, 2015
Expires
Max points
100
Description

Design a protein dimer with C2 cyclic symmetry! This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for FoldIt@Netherlands 21. FoldIt@Netherlands 1 pt. 2,280
  2. Avatar for BOINC@Poland 22. BOINC@Poland 1 pt. 0
  3. Avatar for DSN @ Home 23. DSN @ Home 1 pt. 0
  4. Avatar for Marshall University PS 110 Spring 2015 24. Marshall University PS 110 Spring 2015 1 pt. 0
  5. Avatar for Chem233W15 25. Chem233W15 1 pt. 0
  6. Avatar for Minions of TWIS 26. Minions of TWIS 1 pt. 0
  7. Avatar for Window Group 27. Window Group 1 pt. 0
  1. Avatar for justjustin 21. justjustin Lv 1 62 pts. 12,842
  2. Avatar for Glen B 22. Glen B Lv 1 61 pts. 12,833
  3. Avatar for spvincent 23. spvincent Lv 1 59 pts. 12,820
  4. Avatar for grogar7 24. grogar7 Lv 1 58 pts. 12,810
  5. Avatar for pvc78 25. pvc78 Lv 1 56 pts. 12,789
  6. Avatar for mirp 26. mirp Lv 1 55 pts. 12,774
  7. Avatar for Sissue 27. Sissue Lv 1 54 pts. 12,680
  8. Avatar for dembones 28. dembones Lv 1 52 pts. 12,667
  9. Avatar for crpainter 29. crpainter Lv 1 51 pts. 12,657
  10. Avatar for christioanchauvin 30. christioanchauvin Lv 1 50 pts. 12,653

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 54 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Bruno Kestemont Lv 1

I shared with scientists (>1 day too late) a rank 3 solution @ 13.510.630 pts:

I suppose it's not usefull anymore but it was fun.