Placeholder image of a protein
Icon representing a puzzle

1075: 75 Residue Monomer Design: More Sheets!

Closed since almost 11 years ago

Intermediate Overall Design

Summary

Created
April 13, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues, and extra beta sheets! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for HMT heritage 11. HMT heritage 11 pts. 9,104
  2. Avatar for Natural Abilities 12. Natural Abilities 9 pts. 7,933
  3. Avatar for freefolder 13. freefolder 7 pts. 7,570
  4. Avatar for Russian team 14. Russian team 5 pts. 6,033
  5. Avatar for Eὕρηκα! Heureka! 15. Eὕρηκα! Heureka! 4 pts. 4,735
  6. Avatar for Piratenpartei Deutschland 16. Piratenpartei Deutschland 3 pts. 4,564
  7. Avatar for FoldIt@Netherlands 17. FoldIt@Netherlands 2 pts. 4,341
  8. Avatar for BOINC@Poland 18. BOINC@Poland 1 pt. 3,192
  9. Avatar for Waverki 19. Waverki 1 pt. 3,062
  10. Avatar for Deleted group 20. Deleted group pts. 3,058
  1. Avatar for Azukay 151. Azukay Lv 1 1 pt. 3,227
  2. Avatar for kitek314_pl 152. kitek314_pl Lv 1 1 pt. 3,192
  3. Avatar for 341441 153. 341441 Lv 1 1 pt. 3,159
  4. Avatar for Gatsby1856 154. Gatsby1856 Lv 1 1 pt. 3,127
  5. Avatar for cherry39 155. cherry39 Lv 1 1 pt. 3,093
  6. Avatar for Arne Heessels 156. Arne Heessels Lv 1 1 pt. 3,063
  7. Avatar for Waverka33 157. Waverka33 Lv 1 1 pt. 3,062
  8. Avatar for Savas 158. Savas Lv 1 1 pt. 3,058
  9. Avatar for Carrie Moreno 159. Carrie Moreno Lv 1 1 pt. 3,058
  10. Avatar for DrMoreau 160. DrMoreau Lv 1 1 pt. 2,991

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.