Placeholder image of a protein
Icon representing a puzzle

1075: 75 Residue Monomer Design: More Sheets!

Closed since almost 11 years ago

Intermediate Overall Design

Summary

Created
April 13, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues, and extra beta sheets! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for HMT heritage 11. HMT heritage 11 pts. 9,104
  2. Avatar for Natural Abilities 12. Natural Abilities 9 pts. 7,933
  3. Avatar for freefolder 13. freefolder 7 pts. 7,570
  4. Avatar for Russian team 14. Russian team 5 pts. 6,033
  5. Avatar for Eὕρηκα! Heureka! 15. Eὕρηκα! Heureka! 4 pts. 4,735
  6. Avatar for Piratenpartei Deutschland 16. Piratenpartei Deutschland 3 pts. 4,564
  7. Avatar for FoldIt@Netherlands 17. FoldIt@Netherlands 2 pts. 4,341
  8. Avatar for BOINC@Poland 18. BOINC@Poland 1 pt. 3,192
  9. Avatar for Waverki 19. Waverki 1 pt. 3,062
  10. Avatar for Deleted group 20. Deleted group pts. 3,058
  1. Avatar for frood66 11. frood66 Lv 1 81 pts. 10,122
  2. Avatar for nemo7731 12. nemo7731 Lv 1 79 pts. 10,109
  3. Avatar for johnmitch 13. johnmitch Lv 1 77 pts. 10,084
  4. Avatar for Skippysk8s 14. Skippysk8s Lv 1 75 pts. 10,077
  5. Avatar for pvc78 15. pvc78 Lv 1 74 pts. 10,074
  6. Avatar for dembones 16. dembones Lv 1 72 pts. 10,035
  7. Avatar for karstenw 17. karstenw Lv 1 70 pts. 10,034
  8. Avatar for stomjoh 18. stomjoh Lv 1 69 pts. 10,017
  9. Avatar for Bletchley Park 19. Bletchley Park Lv 1 67 pts. 10,014
  10. Avatar for fryguy 20. fryguy Lv 1 65 pts. 10,012

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.