Placeholder image of a protein
Icon representing a puzzle

1075: 75 Residue Monomer Design: More Sheets!

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
April 13, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues, and extra beta sheets! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Go Science 100 pts. 10,361
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 84 pts. 10,323
  3. Avatar for Beta Folders 3. Beta Folders 70 pts. 10,249
  4. Avatar for Void Crushers 4. Void Crushers 57 pts. 10,223
  5. Avatar for Contenders 5. Contenders 47 pts. 10,166
  6. Avatar for Gargleblasters 6. Gargleblasters 38 pts. 10,138
  7. Avatar for xkcd 7. xkcd 30 pts. 10,012
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 24 pts. 9,968
  9. Avatar for Deleted group 9. Deleted group pts. 9,794
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 15 pts. 9,633

  1. Avatar for meatexplosion 71. meatexplosion Lv 1 17 pts. 8,395
  2. Avatar for mitarcher 72. mitarcher Lv 1 16 pts. 8,368
  3. Avatar for viosca 73. viosca Lv 1 16 pts. 8,345
  4. Avatar for Festering Wounds 74. Festering Wounds Lv 1 15 pts. 8,340
  5. Avatar for gurch 75. gurch Lv 1 15 pts. 8,315
  6. Avatar for PrettyPony2001 76. PrettyPony2001 Lv 1 14 pts. 8,303
  7. Avatar for Bushman 77. Bushman Lv 1 14 pts. 8,273
  8. Avatar for Iron pet 78. Iron pet Lv 1 14 pts. 8,186
  9. Avatar for guineapig 79. guineapig Lv 1 13 pts. 8,153
  10. Avatar for Deleted player 80. Deleted player pts. 8,134

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.