Placeholder image of a protein
Icon representing a puzzle

1076: Vancomycin Binder Design

Closed since about 11 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design

Summary

Created
April 16, 2015
Expires
Max points
100
Description

Design a binding pocket for vancomycin! Scientists in the Baker Lab are trying to design proteins that can bind vancomycin and upon binding generate a signal. With this technology it would be possible to test patients that have been treated with antibiotics if they still have small amounts left before they leave e.g. a hospital. The aim of this puzzle is to optimize the interaction between a protein and the small molecule vancomycin. This puzzle has four different starting structures, all with slightly different residues at the binding site; resetting the puzzle will cycle through the different models.

Top groups

  1. Avatar for Minions of TWIS 21. Minions of TWIS 1 pt. 9,056
  2. Avatar for Deleted group 22. Deleted group pts. 9,056
  3. Avatar for Czech National Team 23. Czech National Team 1 pt. 8,832
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 8,757
  5. Avatar for Window Group 25. Window Group 1 pt. 7,762
  1. Avatar for mbinfield 151. mbinfield Lv 1 2 pts. 9,091
  2. Avatar for trentis1 152. trentis1 Lv 1 2 pts. 9,088
  3. Avatar for IgorS 153. IgorS Lv 1 1 pt. 9,088
  4. Avatar for cnhrcolemam 154. cnhrcolemam Lv 1 1 pt. 9,086
  5. Avatar for dbuske 155. dbuske Lv 1 1 pt. 9,086
  6. Avatar for Sydefecks 156. Sydefecks Lv 1 1 pt. 9,084
  7. Avatar for emdee314 157. emdee314 Lv 1 1 pt. 9,083
  8. Avatar for s2barcla 158. s2barcla Lv 1 1 pt. 9,083
  9. Avatar for lzhchild 159. lzhchild Lv 1 1 pt. 9,077
  10. Avatar for Jules_Ngal 160. Jules_Ngal Lv 1 1 pt. 9,077

Comments