Placeholder image of a protein
Icon representing a puzzle

1076: Vancomycin Binder Design

Closed since almost 11 years ago

Intermediate Overall Design

Summary

Created
April 16, 2015
Expires
Max points
100
Description

Design a binding pocket for vancomycin! Scientists in the Baker Lab are trying to design proteins that can bind vancomycin and upon binding generate a signal. With this technology it would be possible to test patients that have been treated with antibiotics if they still have small amounts left before they leave e.g. a hospital. The aim of this puzzle is to optimize the interaction between a protein and the small molecule vancomycin. This puzzle has four different starting structures, all with slightly different residues at the binding site; resetting the puzzle will cycle through the different models.

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 9,658
  2. Avatar for Beta Folders 2. Beta Folders 81 pts. 9,649
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 65 pts. 9,636
  4. Avatar for L'Alliance Francophone 4. L'Alliance Francophone 52 pts. 9,627
  5. Avatar for Contenders 5. Contenders 41 pts. 9,620
  6. Avatar for Russian team 6. Russian team 32 pts. 9,609
  7. Avatar for Void Crushers 7. Void Crushers 24 pts. 9,590
  8. Avatar for HMT heritage 8. HMT heritage 18 pts. 9,590
  9. Avatar for Gargleblasters 9. Gargleblasters 14 pts. 9,585
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 10 pts. 9,508
  1. Avatar for Gatsby1856 181. Gatsby1856 Lv 1 1 pt. 9,051
  2. Avatar for 1143btbt 182. 1143btbt Lv 1 1 pt. 9,050
  3. Avatar for momadoc 183. momadoc Lv 1 1 pt. 9,050
  4. Avatar for Dantoto 184. Dantoto Lv 1 1 pt. 9,049
  5. Avatar for Sigian 185. Sigian Lv 1 1 pt. 9,045
  6. Avatar for Keiken 186. Keiken Lv 1 1 pt. 9,045
  7. Avatar for tornado163 187. tornado163 Lv 1 1 pt. 9,035
  8. Avatar for cherry39 188. cherry39 Lv 1 1 pt. 9,033
  9. Avatar for karost 189. karost Lv 1 1 pt. 9,018
  10. Avatar for navn 190. navn Lv 1 1 pt. 9,017

Comments