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1090: 80 Residue Symmetric Dimer Design

Closed since almost 11 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 19, 2015
Expires
Max points
100
Description

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Minions of TWIS 21. Minions of TWIS 1 pt. 0
  2. Avatar for Window Group 22. Window Group 1 pt. 0
  3. Avatar for BOINC@Poland 23. BOINC@Poland 1 pt. 0
  4. Avatar for Team Schleswig-Holstein 24. Team Schleswig-Holstein 1 pt. 0
  1. Avatar for momadoc 171. momadoc Lv 1 1 pt. 0
  2. Avatar for karstenw 172. karstenw Lv 1 1 pt. 0
  3. Avatar for cfgmaster 173. cfgmaster Lv 1 1 pt. 0
  4. Avatar for nournegm85 174. nournegm85 Lv 1 1 pt. 0
  5. Avatar for Skippysk8s 175. Skippysk8s Lv 1 1 pt. 0
  6. Avatar for isaksson 176. isaksson Lv 1 1 pt. 0
  7. Avatar for IgorS 177. IgorS Lv 1 1 pt. 0
  8. Avatar for agnairt 178. agnairt Lv 1 1 pt. 0
  9. Avatar for thegr8guitar 179. thegr8guitar Lv 1 1 pt. 0
  10. Avatar for Bithalbierer 180. Bithalbierer Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 22 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 50 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Bruno Kestemont Lv 1

I've a solution with all bonus ok including core existence complex BUT my 2 monomers are still far away from each other …

bkoep Staff Lv 1

This came up in Puzzle 1068, as well:
http://fold.it/portal/node/2000548#comment-30118

If your monomer units are especially well-packed, it is possible to pass the "Core Existence: Complex" filter without designing an interface. We've intentionally set a low threshold here to allow more diversity in designs.

At some point, we might change the filter behavior so this isn't possible; but for the time being, I encourage you to design an interface in spite of your filter bonus!

martin.szew Lv 1

Just a thought maybe in future puzzle you can increase the bonus in the Core Existence: Complex for interaction and give more freedom with a lower requirement for Core Existence: Monomer.