Placeholder image of a protein
Icon representing a puzzle

1090: 80 Residue Symmetric Dimer Design

Closed since almost 11 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 19, 2015
Expires
Max points
100
Description

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 13,664
  2. Avatar for Gargleblasters 2. Gargleblasters 81 pts. 13,517
  3. Avatar for Void Crushers 3. Void Crushers 64 pts. 13,379
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 50 pts. 13,378
  5. Avatar for Go Science 5. Go Science 39 pts. 13,327
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 30 pts. 13,307
  7. Avatar for Contenders 7. Contenders 23 pts. 13,204
  8. Avatar for HMT heritage 8. HMT heritage 17 pts. 13,171
  9. Avatar for Deleted group 9. Deleted group pts. 12,754
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 9 pts. 11,041
  1. Avatar for pmdpmd 61. pmdpmd Lv 1 22 pts. 11,380
  2. Avatar for drumpeter18yrs9yrs 62. drumpeter18yrs9yrs Lv 1 21 pts. 11,344
  3. Avatar for joremen 63. joremen Lv 1 20 pts. 11,135
  4. Avatar for deLaCeiba 64. deLaCeiba Lv 1 20 pts. 11,041
  5. Avatar for erikviking 65. erikviking Lv 1 19 pts. 11,041
  6. Avatar for ponderosa 66. ponderosa Lv 1 19 pts. 11,008
  7. Avatar for goastano 67. goastano Lv 1 18 pts. 10,993
  8. Avatar for tallguy-13088 68. tallguy-13088 Lv 1 18 pts. 10,966
  9. Avatar for arginia 69. arginia Lv 1 17 pts. 10,541
  10. Avatar for phi16 70. phi16 Lv 1 17 pts. 10,325

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 22 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 50 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Bruno Kestemont Lv 1

I've a solution with all bonus ok including core existence complex BUT my 2 monomers are still far away from each other …

bkoep Staff Lv 1

This came up in Puzzle 1068, as well:
http://fold.it/portal/node/2000548#comment-30118

If your monomer units are especially well-packed, it is possible to pass the "Core Existence: Complex" filter without designing an interface. We've intentionally set a low threshold here to allow more diversity in designs.

At some point, we might change the filter behavior so this isn't possible; but for the time being, I encourage you to design an interface in spite of your filter bonus!

martin.szew Lv 1

Just a thought maybe in future puzzle you can increase the bonus in the Core Existence: Complex for interaction and give more freedom with a lower requirement for Core Existence: Monomer.