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1093: 75 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
May 26, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


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  2. Avatar for Italiani Al Lavoro 12. Italiani Al Lavoro 3 pts. 9,357
  3. Avatar for FoldIt@Netherlands 13. FoldIt@Netherlands 2 pts. 9,030
  4. Avatar for xkcd 14. xkcd 1 pt. 9,004
  5. Avatar for BOINC@Poland 15. BOINC@Poland 1 pt. 8,508
  6. Avatar for Deleted group 16. Deleted group pts. 7,871
  7. Avatar for freefolder 17. freefolder 1 pt. 7,669
  8. Avatar for Eὕρηκα! Heureka! 18. Eὕρηκα! Heureka! 1 pt. 7,658
  9. Avatar for Crunching Family 19. Crunching Family 1 pt. 7,410
  10. Avatar for DSN @ Home 20. DSN @ Home 1 pt. 7,098

  1. Avatar for MiDr 291. MiDr Lv 1 1 pt. 0
  2. Avatar for decbin 292. decbin Lv 1 1 pt. 0
  3. Avatar for greepski 294. greepski Lv 1 1 pt. 0
  4. Avatar for Dantoto 295. Dantoto Lv 1 1 pt. 0
  5. Avatar for packer 296. packer Lv 1 1 pt. 0
  6. Avatar for Suszaraa 297. Suszaraa Lv 1 1 pt. 0
  7. Avatar for Emil Dare 298. Emil Dare Lv 1 1 pt. 0
  8. Avatar for dimmo 299. dimmo Lv 1 1 pt. 0
  9. Avatar for 1s22s22p6 300. 1s22s22p6 Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.