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1093: 75 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
May 26, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Minions of TWIS 22. Minions of TWIS 1 pt. 3,086

  1. Avatar for brgreening 111. brgreening Lv 1 13 pts. 8,225
  2. Avatar for cbwest 112. cbwest Lv 1 13 pts. 8,200
  3. Avatar for Petrifolder 113. Petrifolder Lv 1 12 pts. 8,142
  4. Avatar for mark4mars 114. mark4mars Lv 1 12 pts. 8,133
  5. Avatar for _Conduit_ 115. _Conduit_ Lv 1 12 pts. 8,116
  6. Avatar for lamoille 116. lamoille Lv 1 11 pts. 8,104
  7. Avatar for dahast.de 117. dahast.de Lv 1 11 pts. 8,094
  8. Avatar for 341441 118. 341441 Lv 1 11 pts. 8,091
  9. Avatar for alwen 119. alwen Lv 1 11 pts. 8,073
  10. Avatar for Mateon1 120. Mateon1 Lv 1 10 pts. 8,060

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.