Placeholder image of a protein
Icon representing a puzzle

1093: 75 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
May 26, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Minions of TWIS 22. Minions of TWIS 1 pt. 3,086

  1. Avatar for Lindata 71. Lindata Lv 1 30 pts. 9,016
  2. Avatar for fryguy 72. fryguy Lv 1 29 pts. 9,004
  3. Avatar for sharondipity 73. sharondipity Lv 1 29 pts. 8,965
  4. Avatar for dizzywings 74. dizzywings Lv 1 28 pts. 8,899
  5. Avatar for firejuggler 75. firejuggler Lv 1 28 pts. 8,874
  6. Avatar for Mike Cassidy 76. Mike Cassidy Lv 1 27 pts. 8,814
  7. Avatar for Cyberkashi 77. Cyberkashi Lv 1 27 pts. 8,786
  8. Avatar for Prof. Ethan Duncan 78. Prof. Ethan Duncan Lv 1 26 pts. 8,786
  9. Avatar for arginia 79. arginia Lv 1 25 pts. 8,770
  10. Avatar for isaksson 80. isaksson Lv 1 25 pts. 8,761

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.