1093: 75 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Summary

• Created: May 26, 2015
• Expires: June 02, 2015 at 23:00 UTC
• Max points: 100

Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Beta Folders 100 pts. 10,444
• 2. Anthropic Dreams 79 pts. 10,389
• 3. Gargleblasters 61 pts. 10,343
• 4. L'Alliance Francophone 47 pts. 10,330
• 5. Go Science 35 pts. 10,325
• 6. Contenders 26 pts. 10,286
• 7. Void Crushers 19 pts. 10,275
• 8. Deleted group pts. 9,981
• 9. SETI.Germany 10 pts. 9,833
• 10. Russian team 7 pts. 9,410

Top soloists

• 11. spvincent 86 pts. 10,256
• 12. gmn 85 pts. 10,252
• 13. Madde 83 pts. 10,234
• 14. Bruno Kestemont 82 pts. 10,233
• 15. justjustin 81 pts. 10,229
• 16. Enzyme 79 pts. 10,221
• 17. Museka 78 pts. 10,220
• 18. spmm 77 pts. 10,203
• 19. Blipperman 76 pts. 10,184
• 20. bertro 74 pts. 10,158

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.