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1093: 75 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
May 26, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


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  3. Avatar for Gargleblasters 3. Gargleblasters 61 pts. 10,343
  4. Avatar for L'Alliance Francophone 4. L'Alliance Francophone 47 pts. 10,330
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  6. Avatar for Contenders 6. Contenders 26 pts. 10,286
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  8. Avatar for Deleted group 8. Deleted group pts. 9,981
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  10. Avatar for Russian team 10. Russian team 7 pts. 9,410

  1. Avatar for Bumbulis 302. Bumbulis Lv 1 1 pt. 0
  2. Avatar for roman madala 303. roman madala Lv 1 1 pt. 0
  3. Avatar for yk203 304. yk203 Lv 1 1 pt. 0
  4. Avatar for zelenikovec 305. zelenikovec Lv 1 1 pt. 0
  5. Avatar for kalachastan 306. kalachastan Lv 1 1 pt. 0
  6. Avatar for spezialemic 307. spezialemic Lv 1 1 pt. 0
  7. Avatar for NotJim99 308. NotJim99 Lv 1 1 pt. 0
  8. Avatar for ivalnic 309. ivalnic Lv 1 1 pt. 0
  9. Avatar for The Trooper 310. The Trooper Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.