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1096: 70 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
June 02, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


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  6. Avatar for freefolder 17. freefolder 1 pt. 8,142
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  1. Avatar for Astralist 161. Astralist Lv 1 1 pt. 7,376
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  3. Avatar for brgreening 163. brgreening Lv 1 1 pt. 7,357
  4. Avatar for dahast.de 164. dahast.de Lv 1 1 pt. 7,347
  5. Avatar for Rconix 165. Rconix Lv 1 1 pt. 7,340
  6. Avatar for WBarme1234 166. WBarme1234 Lv 1 1 pt. 7,197
  7. Avatar for Deleted player 167. Deleted player pts. 6,905
  8. Avatar for lamoille 168. lamoille Lv 1 1 pt. 6,878
  9. Avatar for Hongmiao Hu 169. Hongmiao Hu Lv 1 1 pt. 6,465
  10. Avatar for FishKAA 170. FishKAA Lv 1 1 pt. 5,747

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.