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1096: 70 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
June 02, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Italiani Al Lavoro 11. Italiani Al Lavoro 7 pts. 9,457
  2. Avatar for HMT heritage 12. HMT heritage 5 pts. 9,386
  3. Avatar for FoldIt@Netherlands 14. FoldIt@Netherlands 3 pts. 8,890
  4. Avatar for Waverki 15. Waverki 2 pts. 8,409
  5. Avatar for BOINC@Poland 16. BOINC@Poland 1 pt. 8,265
  6. Avatar for freefolder 17. freefolder 1 pt. 8,142
  7. Avatar for foldeRNA 18. foldeRNA 1 pt. 8,124
  8. Avatar for Crunching Family 19. Crunching Family 1 pt. 8,069
  9. Avatar for Eὕρηκα! Heureka! 20. Eὕρηκα! Heureka! 1 pt. 7,705

  1. Avatar for Kren 201. Kren Lv 1 1 pt. 0
  2. Avatar for Flagg65a 203. Flagg65a Lv 1 1 pt. 0
  3. Avatar for bob1928 204. bob1928 Lv 1 1 pt. 0
  4. Avatar for loflav 205. loflav Lv 1 1 pt. 0
  5. Avatar for Satina 206. Satina Lv 1 1 pt. 0
  6. Avatar for sneaky10389 207. sneaky10389 Lv 1 1 pt. 0
  7. Avatar for RTbecard 208. RTbecard Lv 1 1 pt. 0
  8. Avatar for Dantoto 209. Dantoto Lv 1 1 pt. 0
  9. Avatar for sheerbliss 210. sheerbliss Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.