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1096: 70 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
June 02, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for DSN @ Home 21. DSN @ Home 1 pt. 1,968
  2. Avatar for Window Group 22. Window Group 1 pt. 0
  3. Avatar for ROMANIA Team 23. ROMANIA Team 1 pt. 0
  4. Avatar for Minions of TWIS 24. Minions of TWIS 1 pt. 0
  5. Avatar for SETI.Germany 25. SETI.Germany 1 pt. 0

  1. Avatar for ppp6 91. ppp6 Lv 1 8 pts. 8,622
  2. Avatar for SpikRMX 92. SpikRMX Lv 1 8 pts. 8,622
  3. Avatar for harvardman 93. harvardman Lv 1 7 pts. 8,593
  4. Avatar for egran48 94. egran48 Lv 1 7 pts. 8,530
  5. Avatar for t1mn 95. t1mn Lv 1 7 pts. 8,504
  6. Avatar for rinze 96. rinze Lv 1 7 pts. 8,489
  7. Avatar for kentish_alex 97. kentish_alex Lv 1 6 pts. 8,486
  8. Avatar for abiogenesis 98. abiogenesis Lv 1 6 pts. 8,477
  9. Avatar for AryehK 99. AryehK Lv 1 6 pts. 8,472
  10. Avatar for trentis1 100. trentis1 Lv 1 6 pts. 8,453

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.