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1096: 70 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
June 02, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for DSN @ Home 21. DSN @ Home 1 pt. 1,968
  2. Avatar for Window Group 22. Window Group 1 pt. 0
  3. Avatar for ROMANIA Team 23. ROMANIA Team 1 pt. 0
  4. Avatar for Minions of TWIS 24. Minions of TWIS 1 pt. 0
  5. Avatar for SETI.Germany 25. SETI.Germany 1 pt. 0

  1. Avatar for jermainiac 51. jermainiac Lv 1 29 pts. 9,577
  2. Avatar for gloverd 52. gloverd Lv 1 28 pts. 9,491
  3. Avatar for goastano 53. goastano Lv 1 27 pts. 9,469
  4. Avatar for deLaCeiba 54. deLaCeiba Lv 1 26 pts. 9,457
  5. Avatar for georg137 55. georg137 Lv 1 25 pts. 9,415
  6. Avatar for O Seki To 56. O Seki To Lv 1 25 pts. 9,379
  7. Avatar for Bletchley Park 57. Bletchley Park Lv 1 24 pts. 9,367
  8. Avatar for puxatudo 58. puxatudo Lv 1 23 pts. 9,357
  9. Avatar for alwen 59. alwen Lv 1 23 pts. 9,349
  10. Avatar for sharondipity 60. sharondipity Lv 1 22 pts. 9,322

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.