Placeholder image of a protein
Icon representing a puzzle

1106: 80 Residue Monomer Design: Best Fragments

Closed since over 10 years ago

Intermediate Overall Design

Summary


Created
June 25, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Russian team 11. Russian team 7 pts. 9,233
  2. Avatar for FoldIt@Netherlands 12. FoldIt@Netherlands 5 pts. 8,651
  3. Avatar for xkcd 13. xkcd 4 pts. 8,612
  4. Avatar for Natural Abilities 14. Natural Abilities 3 pts. 8,481
  5. Avatar for BOINC@Poland 15. BOINC@Poland 2 pts. 8,241
  6. Avatar for Deleted group 16. Deleted group pts. 7,921
  7. Avatar for Eὕρηκα! Heureka! 17. Eὕρηκα! Heureka! 1 pt. 7,564
  8. Avatar for Dnice.dk 18. Dnice.dk 1 pt. 7,287
  9. Avatar for CureCoin 19. CureCoin 1 pt. 7,146
  10. Avatar for DSN @ Home 20. DSN @ Home 1 pt. 7,023

  1. Avatar for pandabearsecond 171. pandabearsecond Lv 1 1 pt. 6,474
  2. Avatar for Josch123 172. Josch123 Lv 1 1 pt. 6,427
  3. Avatar for andrewxc 173. andrewxc Lv 1 1 pt. 6,191
  4. Avatar for Andi1960 174. Andi1960 Lv 1 1 pt. 5,059
  5. Avatar for lilovip 175. lilovip Lv 1 1 pt. 4,917
  6. Avatar for Jim Fraser 176. Jim Fraser Lv 1 1 pt. 4,903
  7. Avatar for steveB 177. steveB Lv 1 1 pt. 4,888
  8. Avatar for FishKAA 178. FishKAA Lv 1 1 pt. 4,604
  9. Avatar for lamoille 179. lamoille Lv 1 1 pt. 4,340
  10. Avatar for lzhchild 180. lzhchild Lv 1 1 pt. 4,287

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.