Placeholder image of a protein
Icon representing a puzzle

1106: 80 Residue Monomer Design: Best Fragments

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
June 25, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for freefolder 21. freefolder 1 pt. 0
  2. Avatar for SETI.Germany 22. SETI.Germany 1 pt. 0
  3. Avatar for Minions of TWIS 23. Minions of TWIS 1 pt. 0
  4. Avatar for Team Schleswig-Holstein 24. Team Schleswig-Holstein 1 pt. 0
  5. Avatar for Team Germany 25. Team Germany 1 pt. 0
  1. Avatar for martinf 151. martinf Lv 1 1 pt. 7,327
  2. Avatar for dettingen 152. dettingen Lv 1 1 pt. 7,318
  3. Avatar for emdee314 153. emdee314 Lv 1 1 pt. 7,317
  4. Avatar for cherry39 154. cherry39 Lv 1 1 pt. 7,311
  5. Avatar for DScott 155. DScott Lv 1 1 pt. 7,300
  6. Avatar for armaholik 156. armaholik Lv 1 1 pt. 7,297
  7. Avatar for pumtex 157. pumtex Lv 1 1 pt. 7,287
  8. Avatar for mirjamvandelft 158. mirjamvandelft Lv 1 1 pt. 7,227
  9. Avatar for smarthuman 159. smarthuman Lv 1 1 pt. 7,146
  10. Avatar for leader425 160. leader425 Lv 1 1 pt. 7,034

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.