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1106: 80 Residue Monomer Design: Best Fragments

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
June 25, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for freefolder 21. freefolder 1 pt. 0
  2. Avatar for SETI.Germany 22. SETI.Germany 1 pt. 0
  3. Avatar for Minions of TWIS 23. Minions of TWIS 1 pt. 0
  4. Avatar for Team Schleswig-Holstein 24. Team Schleswig-Holstein 1 pt. 0
  5. Avatar for Team Germany 25. Team Germany 1 pt. 0
  1. Avatar for g_b 31. g_b Lv 1 52 pts. 10,109
  2. Avatar for Sissue 32. Sissue Lv 1 51 pts. 10,098
  3. Avatar for Mike Cassidy 33. Mike Cassidy Lv 1 50 pts. 10,085
  4. Avatar for grogar7 34. grogar7 Lv 1 48 pts. 10,081
  5. Avatar for pauldunn 35. pauldunn Lv 1 47 pts. 10,072
  6. Avatar for crpainter 36. crpainter Lv 1 46 pts. 10,048
  7. Avatar for christioanchauvin 37. christioanchauvin Lv 1 45 pts. 10,034
  8. Avatar for Wilm 38. Wilm Lv 1 44 pts. 10,030
  9. Avatar for spmm 39. spmm Lv 1 43 pts. 9,992
  10. Avatar for gurra66 40. gurra66 Lv 1 42 pts. 9,931

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.