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1106: 80 Residue Monomer Design: Best Fragments

Closed since over 10 years ago

Intermediate Overall Design

Summary


Created
June 25, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for freefolder 21. freefolder 1 pt. 0
  2. Avatar for SETI.Germany 22. SETI.Germany 1 pt. 0
  3. Avatar for Minions of TWIS 23. Minions of TWIS 1 pt. 0
  4. Avatar for Team Germany 25. Team Germany 1 pt. 0

  1. Avatar for Close At Hand 61. Close At Hand Lv 1 24 pts. 9,003
  2. Avatar for weitzen 62. weitzen Lv 1 24 pts. 8,944
  3. Avatar for cbwest 63. cbwest Lv 1 23 pts. 8,917
  4. Avatar for arginia 64. arginia Lv 1 22 pts. 8,910
  5. Avatar for sharondipity 65. sharondipity Lv 1 22 pts. 8,853
  6. Avatar for egran48 66. egran48 Lv 1 21 pts. 8,809
  7. Avatar for SouperGenious 67. SouperGenious Lv 1 21 pts. 8,803
  8. Avatar for karost 68. karost Lv 1 20 pts. 8,796
  9. Avatar for silverberg 69. silverberg Lv 1 20 pts. 8,723
  10. Avatar for Viacheslav Pivovarov 70. Viacheslav Pivovarov Lv 1 19 pts. 8,709

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.