1106: 80 Residue Monomer Design: Best Fragments

Closed since over 10 years ago

Summary

• Created: June 25, 2015
• Expires: July 02, 2015 at 23:00 UTC
• Max points: 100

Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Beta Folders 100 pts. 10,598
• 2. Anthropic Dreams 81 pts. 10,558
• 3. Contenders 65 pts. 10,502
• 4. Go Science 52 pts. 10,446
• 5. Gargleblasters 41 pts. 10,364
• 6. Void Crushers 32 pts. 10,362
• 7. L'Alliance Francophone 24 pts. 10,353
• 8. HMT heritage 18 pts. 10,291
• 9. Deleted group pts. 10,287
• 10. Italiani Al Lavoro 10 pts. 9,311

Top soloists

• 11. Bruno Kestemont 81 pts. 10,362
• 12. Timo van der Laan 80 pts. 10,362
• 13. nicobul 78 pts. 10,353
• 14. LociOiling 76 pts. 10,309
• 15. TomTaylor 75 pts. 10,308
• 16. Galaxie 73 pts. 10,306
• 17. Museka 71 pts. 10,305
• 18. O Seki To 70 pts. 10,290
• 19. Vredeman 68 pts. 10,249
• 20. stomjoh 67 pts. 10,235

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.