Placeholder image of a protein
Icon representing a puzzle

1115: 80 Residue Symmetric Trimer Design: HBNet

Closed since over 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
July 17, 2015
Expires
Max points
100
Description

This puzzle combines the new HBNet filter with full-blown symmetric design. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for xkcd 11. xkcd 4 pts. 10,257
  2. Avatar for Natural Abilities 12. Natural Abilities 2 pts. 8,618
  3. Avatar for FoldIt@Netherlands 13. FoldIt@Netherlands 2 pts. 7,961
  4. Avatar for HMT heritage 14. HMT heritage 1 pt. 7,474
  5. Avatar for Deleted group 15. Deleted group pts. 6,183
  6. Avatar for CureCoin 16. CureCoin 1 pt. 1,259
  7. Avatar for DSN @ Home 17. DSN @ Home 1 pt. 978
  8. Avatar for freefolder 18. freefolder 1 pt. 0
  9. Avatar for Minions of TWIS 19. Minions of TWIS 1 pt. 0
  10. Avatar for Russian team 20. Russian team 1 pt. 0
  1. Avatar for Deleted player 11. Deleted player pts. 13,296
  2. Avatar for hpaege 12. hpaege Lv 1 78 pts. 13,250
  3. Avatar for gloverd 13. gloverd Lv 1 76 pts. 13,240
  4. Avatar for dembones 14. dembones Lv 1 75 pts. 13,230
  5. Avatar for silverberg 15. silverberg Lv 1 73 pts. 13,163
  6. Avatar for Bruno Kestemont 16. Bruno Kestemont Lv 1 71 pts. 13,155
  7. Avatar for caglar 17. caglar Lv 1 69 pts. 13,139
  8. Avatar for Timo van der Laan 18. Timo van der Laan Lv 1 68 pts. 13,137
  9. Avatar for Galaxie 19. Galaxie Lv 1 66 pts. 13,113
  10. Avatar for gitwut 20. gitwut Lv 1 65 pts. 13,103

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with at least one hydrogen bond spanning the dimer interface.

Core Existence: Monomer: Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 81 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!