Placeholder image of a protein
Icon representing a puzzle

1118: 80 Residue Symmetric Trimer Design: Satisfied H-bonds

Closed since over 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
July 25, 2015
Expires
Max points
100
Description

This puzzle is very similar to Puzzle 1115, though the HBNet filter has been slightly tweaked. In this puzzle, the bonus for H-bond networks has been doubled, but only Hbond networks that are at least 75% satisfied will be rewarded. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Natural Abilities 11. Natural Abilities 4 pts. 10,257
  2. Avatar for freefolder 12. freefolder 3 pts. 9,654
  3. Avatar for Deleted group 13. Deleted group pts. 8,293
  4. Avatar for HMT heritage 14. HMT heritage 1 pt. 7,409
  5. Avatar for FoldIt@Netherlands 15. FoldIt@Netherlands 1 pt. 6,328
  6. Avatar for foldeRNA 16. foldeRNA 1 pt. 5,575
  7. Avatar for CureCoin 17. CureCoin 1 pt. 3,134
  8. Avatar for Eὕρηκα! Heureka! 18. Eὕρηκα! Heureka! 1 pt. 2,641
  9. Avatar for BOINC@Poland 19. BOINC@Poland 1 pt. 1,615
  10. Avatar for DSN @ Home 20. DSN @ Home 1 pt. 0
  1. Avatar for johnmitch 11. johnmitch Lv 1 79 pts. 13,671
  2. Avatar for martin.szew 12. martin.szew Lv 1 77 pts. 13,670
  3. Avatar for Blipperman 13. Blipperman Lv 1 75 pts. 13,567
  4. Avatar for Galaxie 14. Galaxie Lv 1 73 pts. 13,503
  5. Avatar for Timo van der Laan 15. Timo van der Laan Lv 1 71 pts. 13,436
  6. Avatar for reefyrob 16. reefyrob Lv 1 70 pts. 13,429
  7. Avatar for gmn 17. gmn Lv 1 68 pts. 13,380
  8. Avatar for cbwest 18. cbwest Lv 1 66 pts. 13,370
  9. Avatar for actiasluna 19. actiasluna Lv 1 65 pts. 13,262
  10. Avatar for Bletchley Park 20. Bletchley Park Lv 1 63 pts. 13,252

Comments

grogar7 Lv 1

I appear to be receiving bonuses for H-bond nets that are less than 75% satisfied?!

Bautho Lv 1

I agree,
especially the time for building again a nice structure with no bad fragments =D

martin.szew Lv 1

I will post the solution after this puzzle finished.

Meanwhile, I guess that the Hbond network is linked to the bonds sidechain. However you need at least one bond in the interfase and at least three bonds to be considered a network.

In this particular case with a trimer We all get a 3 simetry so in theory we can get some AA to automake an HBN.

For me it was helpful to get plenty of examples of HBN from previous puzles. In particular distances and frequency of AA and a lot of luck with récipes with mutation + wiggle + shake.