Placeholder image of a protein
Icon representing a puzzle

1118: 80 Residue Symmetric Trimer Design: Satisfied H-bonds

Closed since over 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
July 25, 2015
Expires
Max points
100
Description

This puzzle is very similar to Puzzle 1115, though the HBNet filter has been slightly tweaked. In this puzzle, the bonus for H-bond networks has been doubled, but only Hbond networks that are at least 75% satisfied will be rewarded. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 14,563
  2. Avatar for Beta Folders 2. Beta Folders 79 pts. 14,339
  3. Avatar for L'Alliance Francophone 3. L'Alliance Francophone 61 pts. 14,286
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 47 pts. 14,257
  5. Avatar for Gargleblasters 5. Gargleblasters 35 pts. 13,674
  6. Avatar for Void Crushers 6. Void Crushers 26 pts. 13,436
  7. Avatar for Contenders 7. Contenders 19 pts. 13,264
  8. Avatar for Deleted group 8. Deleted group pts. 12,809
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 10 pts. 11,922
  10. Avatar for xkcd 10. xkcd 7 pts. 11,297
  1. Avatar for Sissue 41. Sissue Lv 1 35 pts. 12,583
  2. Avatar for Iron pet 42. Iron pet Lv 1 34 pts. 12,566
  3. Avatar for steveB 43. steveB Lv 1 33 pts. 12,523
  4. Avatar for Anfinsen_slept_here 44. Anfinsen_slept_here Lv 1 32 pts. 12,387
  5. Avatar for pvc78 45. pvc78 Lv 1 32 pts. 12,328
  6. Avatar for Bautho 46. Bautho Lv 1 31 pts. 12,305
  7. Avatar for georg137 47. georg137 Lv 1 30 pts. 12,260
  8. Avatar for shettler 48. shettler Lv 1 29 pts. 12,089
  9. Avatar for jobo0502 49. jobo0502 Lv 1 28 pts. 11,981
  10. Avatar for deLaCeiba 50. deLaCeiba Lv 1 27 pts. 11,922

Comments

grogar7 Lv 1

I appear to be receiving bonuses for H-bond nets that are less than 75% satisfied?!

Bautho Lv 1

I agree,
especially the time for building again a nice structure with no bad fragments =D

martin.szew Lv 1

I will post the solution after this puzzle finished.

Meanwhile, I guess that the Hbond network is linked to the bonds sidechain. However you need at least one bond in the interfase and at least three bonds to be considered a network.

In this particular case with a trimer We all get a 3 simetry so in theory we can get some AA to automake an HBN.

For me it was helpful to get plenty of examples of HBN from previous puzles. In particular distances and frequency of AA and a lot of luck with récipes with mutation + wiggle + shake.