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1125: 60 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary


Created
August 12, 2015
Expires
Max points
100
Description

This is a small 60 residue design puzzle. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Deleted group 11. Deleted group pts. 9,533
  2. Avatar for freefolder 12. freefolder 2 pts. 9,277
  3. Avatar for FoldIt@Netherlands 13. FoldIt@Netherlands 2 pts. 8,921
  4. Avatar for BOINC@Poland 14. BOINC@Poland 1 pt. 8,686
  5. Avatar for CureCoin 15. CureCoin 1 pt. 7,926
  6. Avatar for xkcd 16. xkcd 1 pt. 7,506
  7. Avatar for Natural Abilities 18. Natural Abilities 1 pt. 5,874
  8. Avatar for ROMANIA Team 19. ROMANIA Team 1 pt. 5,527
  9. Avatar for DSN @ Home 20. DSN @ Home 1 pt. 4,150

  1. Avatar for rezaefar 111. rezaefar Lv 1 4 pts. 8,485
  2. Avatar for sharondipity 112. sharondipity Lv 1 3 pts. 8,480
  3. Avatar for DingDangDong 113. DingDangDong Lv 1 3 pts. 8,470
  4. Avatar for brgreening 114. brgreening Lv 1 3 pts. 8,459
  5. Avatar for jencimons 115. jencimons Lv 1 3 pts. 8,456
  6. Avatar for parsnip 116. parsnip Lv 1 3 pts. 8,437
  7. Avatar for tymaja 117. tymaja Lv 1 3 pts. 8,434
  8. Avatar for martinf 118. martinf Lv 1 3 pts. 8,408
  9. Avatar for Altercomp 119. Altercomp Lv 1 3 pts. 8,403
  10. Avatar for phi16 120. phi16 Lv 1 2 pts. 8,388

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.