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1125: 60 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
August 12, 2015
Expires
Max points
100
Description

This is a small 60 residue design puzzle. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for SETI.Germany 21. SETI.Germany 1 pt. 0
  1. Avatar for Satina 51. Satina Lv 1 28 pts. 9,632
  2. Avatar for pmdpmd 52. pmdpmd Lv 1 27 pts. 9,628
  3. Avatar for andrewxc 53. andrewxc Lv 1 26 pts. 9,627
  4. Avatar for deLaCeiba 54. deLaCeiba Lv 1 26 pts. 9,611
  5. Avatar for proteansoup 55. proteansoup Lv 1 25 pts. 9,598
  6. Avatar for arginia 56. arginia Lv 1 24 pts. 9,598
  7. Avatar for isaksson 57. isaksson Lv 1 23 pts. 9,572
  8. Avatar for alcor29 58. alcor29 Lv 1 23 pts. 9,552
  9. Avatar for RockOn 59. RockOn Lv 1 22 pts. 9,546
  10. Avatar for Amphimixus 60. Amphimixus Lv 1 21 pts. 9,533

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.