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1125: 60 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary


Created
August 12, 2015
Expires
Max points
100
Description

This is a small 60 residue design puzzle. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Anthropic Dreams 100 pts. 10,165
  2. Avatar for Gargleblasters 2. Gargleblasters 78 pts. 10,038
  3. Avatar for Go Science 3. Go Science 60 pts. 10,029
  4. Avatar for Beta Folders 4. Beta Folders 45 pts. 10,024
  5. Avatar for Contenders 5. Contenders 33 pts. 10,011
  6. Avatar for Void Crushers 6. Void Crushers 24 pts. 10,004
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 17 pts. 9,963
  8. Avatar for Deleted group 8. Deleted group pts. 9,956
  9. Avatar for HMT heritage 9. HMT heritage 8 pts. 9,893
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 6 pts. 9,611

  1. Avatar for hada 211. hada Lv 1 1 pt. 0
  2. Avatar for molleke 212. molleke Lv 1 1 pt. 0
  3. Avatar for Kren 213. Kren Lv 1 1 pt. 0
  4. Avatar for Antibrad 214. Antibrad Lv 1 1 pt. 0
  5. Avatar for Schleicher 215. Schleicher Lv 1 1 pt. 0
  6. Avatar for Timoleon 216. Timoleon Lv 1 1 pt. 0
  7. Avatar for sheerbliss 217. sheerbliss Lv 1 1 pt. 0
  8. Avatar for multaq 218. multaq Lv 1 1 pt. 0
  9. Avatar for val.sch67 219. val.sch67 Lv 1 1 pt. 0
  10. Avatar for LandonChuck 220. LandonChuck Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.