Placeholder image of a protein
Icon representing a puzzle

1125: 60 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
August 12, 2015
Expires
Max points
100
Description

This is a small 60 residue design puzzle. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 10,165
  2. Avatar for Gargleblasters 2. Gargleblasters 78 pts. 10,038
  3. Avatar for Go Science 3. Go Science 60 pts. 10,029
  4. Avatar for Beta Folders 4. Beta Folders 45 pts. 10,024
  5. Avatar for Contenders 5. Contenders 33 pts. 10,011
  6. Avatar for Void Crushers 6. Void Crushers 24 pts. 10,004
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 17 pts. 9,963
  8. Avatar for Deleted group 8. Deleted group pts. 9,956
  9. Avatar for HMT heritage 9. HMT heritage 8 pts. 9,893
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 6 pts. 9,611
  1. Avatar for Arne Heessels 121. Arne Heessels Lv 1 2 pts. 8,384
  2. Avatar for FreeFolder 122. FreeFolder Lv 1 2 pts. 8,380
  3. Avatar for dinkelbrot 123. dinkelbrot Lv 1 2 pts. 8,369
  4. Avatar for SouperGenious 124. SouperGenious Lv 1 2 pts. 8,293
  5. Avatar for trentis1 125. trentis1 Lv 1 2 pts. 8,240
  6. Avatar for Udjine 126. Udjine Lv 1 2 pts. 8,232
  7. Avatar for Zac0118 127. Zac0118 Lv 1 2 pts. 8,179
  8. Avatar for Deleted player 128. Deleted player pts. 8,161
  9. Avatar for t012 129. t012 Lv 1 2 pts. 8,133
  10. Avatar for goldfish80 130. goldfish80 Lv 1 2 pts. 8,114

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.