1125: 60 Residue Monomer Design

Closed since over 10 years ago

Summary

• Created: August 12, 2015
• Expires: August 19, 2015 at 23:00 UTC
• Max points: 100

Description

This is a small 60 residue design puzzle. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Anthropic Dreams 100 pts. 10,165
• 2. Gargleblasters 78 pts. 10,038
• 3. Go Science 60 pts. 10,029
• 4. Beta Folders 45 pts. 10,024
• 5. Contenders 33 pts. 10,011
• 6. Void Crushers 24 pts. 10,004
• 7. L'Alliance Francophone 17 pts. 9,963
• 8. Deleted group pts. 9,956
• 9. HMT heritage 8 pts. 9,893
• 10. Italiani Al Lavoro 6 pts. 9,611

Top soloists

• 61. lilovip 21 pts. 9,510
• 62. bamh 20 pts. 9,510
• 63. weitzen 19 pts. 9,503
• 64. Iron pet 19 pts. 9,425
• 65. ponderosa 18 pts. 9,412
• 66. tela 18 pts. 9,412
• 67. silverberg 17 pts. 9,410
• 68. Mike Cassidy 17 pts. 9,404
• 69. pizpot 16 pts. 9,401
• 70. joremen 16 pts. 9,392

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.