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1128: 70 Residue Symmetric Dimer Design: Satisfied H-bonds

Closed since over 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
August 19, 2015
Expires
Max points
100
Description

Players will need the latest update to play this puzzle! This puzzle is very similar to previous H-bond network puzzles, though the HBNet filter has been slightly tweaked. In this puzzle, the bonus for H-bond networks has been doubled, but only Hbond networks that are at least 75% satisfied will be rewarded. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with at least one hydrogen bond spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

retiredmichael Lv 1

shared a couple with scientists, might help figure out the scoring issue
best is 355 hbond 12500 on total with -300 on the complex score

martin.szew Lv 1

Is it posible to get a puzzle with a more stringent interfase requirement? For example a dimer with Core Complex- 2 Core Monomer > 14-17 segments 20%-25% of the total size (70 on this one)

Or even better a trimmer with Core Complex- 3 Core Monomer > 14-17 segments 20%-25% of the total size (70 on this one)