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1131: 60 Residue Symmetric Trimer: Satisfied H-bonds

Closed since over 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
August 26, 2015
Expires
Max points
100
Description

Update: In response to a server outage, the expiration date of this puzzle has been extended to 09/04/2015 - 23:00 GMT.


In this puzzle, the bonus for Hbond networks has been doubled, but only Hbond networks that are at least 75% satisfied will be rewarded. We've also amended this puzzle so that the Core Exists filters should be easier to satisfy. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with at least one hydrogen bond spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 18 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 66 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

martin.szew Lv 1

Is it possible to get for a next Hbond Puzzle instead of a dimer or a trimer a fourmer (is it right in English?) ?

With lower Monomer requirement (20% instead of 30%) and more interfase requirement (30% instead of 20%).

jeff101 Lv 1

1-mer = monomer
2-mer = dimer
3-mer = trimer
4-mer = tetramer
5-mer = pentamer
6-mer = hexamer