Closed since over 10 years ago
Intermediate Intermediate Overall Overall Design DesignNote: This puzzle replaces Puzzle 1157 which was closed early due to a bug.
This is a basic 60 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.
Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.
Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.
if we want phe, tyr, trp, it might be interesting to try an ompx (with f/w/y on the outside), but to make a good barrel would take at least 7-8 sheets, and it is almost impossible with 60 segments.
