Placeholder image of a protein
Icon representing a puzzle

1160: 70 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
November 21, 2015
Expires
Max points
100
Description

This is a basic 70 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for EVHS AP Biology 21. EVHS AP Biology 1 pt. 0
  2. Avatar for It's over 9000! 22. It's over 9000! 1 pt. 0
  1. Avatar for ponderosa 51. ponderosa Lv 1 30 pts. 9,977
  2. Avatar for jobo0502 52. jobo0502 Lv 1 29 pts. 9,961
  3. Avatar for FarzadBekran 53. FarzadBekran Lv 1 29 pts. 9,927
  4. Avatar for cbwest 54. cbwest Lv 1 28 pts. 9,900
  5. Avatar for smilingone 55. smilingone Lv 1 27 pts. 9,896
  6. Avatar for mimi 56. mimi Lv 1 26 pts. 9,876
  7. Avatar for lynnai 57. lynnai Lv 1 26 pts. 9,869
  8. Avatar for Deleted player 58. Deleted player 25 pts. 9,868
  9. Avatar for sansyo 59. sansyo Lv 1 24 pts. 9,858
  10. Avatar for phi16 60. phi16 Lv 1 24 pts. 9,847

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Vredeman Lv 1

I would and probably others would highly appreciate it if there was someone who would not mind modifying mutate no wiggle from brow to recognise the criteria for the secondary structure design.

It would save a lot of time having to go back and allow GLY, ALA and PRO in loops.

lotsa luv

Porky (soon to be parky)

:)