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1160: 70 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
November 21, 2015
Expires
Max points
100
Description

This is a basic 70 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Vredeman Lv 1

I would and probably others would highly appreciate it if there was someone who would not mind modifying mutate no wiggle from brow to recognise the criteria for the secondary structure design.

It would save a lot of time having to go back and allow GLY, ALA and PRO in loops.

lotsa luv

Porky (soon to be parky)

:)