Placeholder image of a protein
Icon representing a puzzle

1160: 70 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
November 21, 2015
Expires
Max points
100
Description

This is a basic 70 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 10,421
  2. Avatar for Gargleblasters 2. Gargleblasters 79 pts. 10,403
  3. Avatar for Beta Folders 3. Beta Folders 61 pts. 10,391
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 47 pts. 10,341
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 35 pts. 10,328
  6. Avatar for Contenders 6. Contenders 26 pts. 10,311
  7. Avatar for Void Crushers 7. Void Crushers 19 pts. 10,252
  8. Avatar for HMT heritage 8. HMT heritage 14 pts. 10,145
  9. Avatar for Deleted group 9. Deleted group pts. 9,977
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 7 pts. 9,815
  1. Avatar for hansvandenhof 21. hansvandenhof Lv 1 64 pts. 10,208
  2. Avatar for WarpSpeed 22. WarpSpeed Lv 1 63 pts. 10,204
  3. Avatar for TomTaylor 23. TomTaylor Lv 1 61 pts. 10,196
  4. Avatar for diamond_dust 24. diamond_dust Lv 1 60 pts. 10,196
  5. Avatar for shettler 25. shettler Lv 1 58 pts. 10,195
  6. Avatar for actiasluna 26. actiasluna Lv 1 57 pts. 10,184
  7. Avatar for nicobul 27. nicobul Lv 1 56 pts. 10,172
  8. Avatar for gmn 28. gmn Lv 1 54 pts. 10,169
  9. Avatar for BitSpawn 29. BitSpawn Lv 1 53 pts. 10,167
  10. Avatar for Galaxie 30. Galaxie Lv 1 52 pts. 10,166

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Vredeman Lv 1

I would and probably others would highly appreciate it if there was someone who would not mind modifying mutate no wiggle from brow to recognise the criteria for the secondary structure design.

It would save a lot of time having to go back and allow GLY, ALA and PRO in loops.

lotsa luv

Porky (soon to be parky)

:)