1169: 75 Residue Monomer Design

Closed since over 10 years ago

Summary

• Created: December 11, 2015
• Expires: December 18, 2015 at 23:00 UTC
• Max points: 100

Description

This is a basic 75 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 11. Italiani Al Lavoro 3 pts. 9,877
• 12. BOINC@Poland 2 pts. 9,486
• 13. Freedom Folders 1 pt. 9,042
• 14. freefolder 1 pt. 8,442
• 15. Deleted group pts. 7,879
• 16. CureCoin 1 pt. 7,213
• 17. NYIT OW BIOL-340 Fall 2015 1 pt. 7,184
• 18. SHELL 1 pt. 2,866
• 19. Team South Africa 1 pt. 0
• 20. Natural Abilities 1 pt. 0

Top evolvers

• 1. Galaxie 100 pts. 10,502
• 2. Skippysk8s 87 pts. 10,495
• 3. actiasluna 74 pts. 10,493
• 4. egran48 64 pts. 10,491
• 5. MaartenDesnouck 54 pts. 10,490
• 6. Blipperman 46 pts. 10,490
• 7. lamoille 38 pts. 10,490
• 8. viosca 32 pts. 10,488
• 9. ManVsYard 27 pts. 10,488
• 10. reefyrob 22 pts. 10,488

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.